For premedication, the recommended midazolam dosage is 0.07 to 0.08 mg/kg IM (usual dose is about 5 mg IM for an average adult) administered 30 to 60 minutes preoperatively. Lower doses should be used in elderly or debilitated patients. In a study of patients 60 years or older who did not receive concomitant narcotics, 2 […]
Midazolam infusion can be used either alone or combined with a narcotic immediately before the procedure, with supplemental doses to maintain the desired level of sedation throughout the procedure. For short endoscopic or short diagnostic procedures and direct current cardioversion, midazolam infusion of 1 mg/mL formulation is recommended for IV sedation to facilitate slow injection.
For induction of general anesthesia before administration of other anesthetic agents, Individual response to midazolam drip is variable, particularly when a narcotic premedicant is not used. The dosage should be titrated according to the patient’s age and clinical status. Midazolam drip is administered over 20 to 30 seconds, allowing 2 minutes for effect. The recommended
The manifestations of midazolam overdose are sedation, somnolence, confusion, impaired coordination, diminished reflexes, and untoward effects on vital signs, coma and possible cardio respiratory arrest. Treatment of midazolam overdose is the same as that followed for overdosage with other benzodiazepines. Continuous monitoring of vital signs including ECG should be immediately instituted and general supportive measures
Midazolam can be used intravenously for induction of anesthesia versed . As an inducing agent it produces sleep and amnesia but it does not have any analgesic effect. Midazolam is not as rapid acting as thiopental. At approximately equipotent doses (loss of consciousness), thiopental abolishes the eyelash reflex 50—100% faster than midazolam, but it produces
The versed side effects related to Respiratory are respiratory arrest, respiratory failure, apnoea, hypoxia, oxygen desaturation. Danger of respiratory disorders may increase when midazolam is administered with opioids. Therefore, the dosage of both agents should be reduced. Limited information is available from published literature regarding the use of midazolam in paediatric patients. However, based on
Flumazenil is the first specific benzodiazepine antagonist, used as a specific antidote in known or suspected benzodiazepine overdose treatment . In addition, flumazenil could be employed to reverse sedation produced by benzodiazepines during general anesthesia and prolonged sedation in intensive care units. Flumazenil is a specific and competitive antagonist at the central benzodiazepine receptor, reversing
Midazolam pediatric dose loading dose may be followed by a continuous IV infusion to maintain the effect. IV loading doses should not be used in neonates. Continuous IV infusion for sedation in critical care settings is important in pediatric patients. To initiate sedation using midazolam, an IV loading dose of 0.05 to 0.2 mg/kg administered
Lorazepam metabolism is done by glucuronidation in order to form pharmacologically inactive metabolites that are excreted by the kidneys. Lorazepam IV is a long-acting benzodiazepine which is more potent sedative and amnesic than midazolam and diazepam. The effects on ventilation, the cardiovascular system, and skeletal muscles resemble those of other benzodiazepines. The elimination half-time is
The sedative midazolam side effects and fluctuations in vital signs were the most frequent findings following parenteral administration of midazolam injection. These are affected by the lightening or deepening of anesthesia, instrumentation, intubation and use of concomitant drugs. The more frequently encountered fluctuations in vital signs of midazolam side effects included decreased tidal volume and/or
