There is an ongoing debate as to whether propofol EEG exhibits pro- or anticoagulant effects, and whether it should be used in patients with epilepsy. In a prospective study, Meyer et al documented propofol EEG as a sedative-hypnotic agent with anticonvulsant properties as shown by depression of spike-wave patterns in children with epilepsy and by […]
The effect of agonist drug of opoid group have a lot of impact as listed: Cough: The cough center in medulla is suppressed, leading to antitussive action. Pure agonists especially related with codeine have pronounced effect. Nausea and Vomiting: The emesis is usually due to direct stimulation of chemoreceptor trigger zone (CTZ) of area postrema of the
Propofol decreases intraocular pressure and therefore has lot of propofol effects A single low dose bolus of propofol used for sedation before cataract surgery caused a moderate reduction in intraocular pressure with minimal side effects. Propofol Effect on Coagulation and Immunity System Some of the propofol effects are discussed here. Propofol does not cause significant coagulation
The versed side effects related to Respiratory are respiratory arrest, respiratory failure, apnoea, hypoxia, oxygen desaturation. Danger of respiratory disorders may increase when midazolam is administered with opioids. Therefore, the dosage of both agents should be reduced. Limited information is available from published literature regarding the use of midazolam in paediatric patients. However, based on
The midazolam half life elimination of IM administration is comparable to that observed following the IV administration. Midazolam is approximately 97% plasma protein-bound in normal subjects. In patients with chronic renal failure, the free fraction of drug in plasma can be significantly higher than in healthy adults. In animals and humans, Midazolam has shown to
Of interest to the clinicians is that, while appearing minimally responsive to endogenous BNP, heart failure patients will effectively respond to exogenously administered BNP which is nesiritide drip. In patients with cardiogenic pulmonary edema due to acute decompensated heart failure, plasma brain natriuretic peptide (BNP) measurements can guide the diagnosis, distinguishing this etiology of dyspnea
It is rapidly distributed in the body with a propofol half life of only around 2 mm and has an efficient hepatic and extra hepatic clearance. Because the total body clearance may exceed liver blood flow, an extrahepatic metabolism or extrarenal elimination has been suggested. Hepatic metabolism is rapid and extensive, resulting in inactive, water-soluble
All barbiturates metabolism is in the liver. In Barbiturates metabolism , the haemodilution in cardiopulmonary bypass (CPB) causes reduction in total drug concentration and protein binding fraction at the onset of CPB. This decrease in protein binding is counteracted by the dilution of unbound drug, resulting in a stable unbound concentration throughout CPB. The inactive metabolites
Two classes of drugs exist GP IIb/IIIa inhibitors that inhibit these platelet effects at the level of the glycoprotein (GP) IIb/IIIa receptor on the platelet surface membrane. The first group are the thienopyridines (clopidogrel and ticlopidine). Current treatments for acute coronary syndromes including unstable angina and non-ST-elevation myocardial infarction now include agents aimed at inhibiting platelet activation,
Acupuncture physiotherapy pain reduction technique is an ancient Chinese modality used for various chronic painful conditions, in addition to non pain related problems like acute asthma, chronic sinusitis, etc. The human body has a life force or energy flowing — Chi. This life force is flowing through various channels — Meridians. The life force (Chi)
