Drugs

Benzodiazepine half life

Benzodiazepine half life is commonly administered through oral, intramuscular and intravenous routes. Intramuscular absorption of diazepam is erratic, whereas midazolam and benzodiazepine half life have good bioavailability through this route. Diazepam and lorazepam are well absorbed from gastrointestinal tract. However, meals and antacids may decrease absorption from the gastrointestinal tract. Midazolam has also been used […]

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Ketamine Metabolism

Ketamine is metabolized extensively by hepatic microsornal enzymes. Ketamine metabolism is demethylated to the corresponding N-desmethyl compound to form norketamine (about 60%) the main metabolite. Norketamine rapidly appears (approximately within 5 minutes) in plasma following ketamine administration and had a terminal half-life of 63.6 +1- 23.9 minutes. In animals, norketamine is one-fifth to one-third as

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