Midazolam, 0.2 mg/kg IV, for induction of intravenous versed anesthesia produces a greater decrease in systemic blood pressure and increase in heart rate than does diazepam, 0.5 mg/kg IV. The haemodynamic effects of midazolam are significant in humans. In normal humans, midazolam, 0.15 mg/kg IV over 15 seconds, produces statistically significant reduction in systolic (5%) […]
The manifestations of midazolam overdose are sedation, somnolence, confusion, impaired coordination, diminished reflexes, and untoward effects on vital signs, coma and possible cardio respiratory arrest. Treatment of midazolam overdose is the same as that followed for overdosage with other benzodiazepines. Continuous monitoring of vital signs including ECG should be immediately instituted and general supportive measures
