Nitric oxide Inhalation may cause selective reversible dose-dependent pulmonary vasodilatation. It improves ventilation and perfusion of lungs, so beneficial in adult respiratory distress syndrome. It helps to reduce pulmonary vascular resistance in patients with primary pulmonary hypertension. It was known to be atmospheric pollutant produced by internal combustion of engines. It possesses various biological functions—there […]
Hyperbaric oxygen therapy is currently used in various clinical treatment regimens like for treating carbon monoxide poisoning. These include decompression sickness, carbon monoxide poisoning, cyanide poisoning, gas embolus, gas gangrene, resistant anaerobic infections, and threatened split-thickness skin grafts. The mechanism of action in treating carbon monoxide poisoning purportedly involves increasing tissue oxygenation, which increases collagen
In adult with normal hemoglobin and hematocrit blood losses more than 20% of their blood volume (or hematocrit falls below 30%) are to be replaced with blood (while in western countries replacement may be required on loss more than 25 to 30%). A few important indications of transfusion of blood are mentioned below. • Losses
The major complications of transfusion of blood are the following: 1. Transfusion Reactions : These reactions may be allergic or haemolytic: Haemolytic Reactions These are again divided in to Delayed Hemolytic reactions and Acute Hemolytic reactions. Allergic Reactions These are usually mild, manifesting as urticaria and are mainly due to plasma proteins. Treatment: Antihistamines (Avil)
The capacity of deliberate Brain Hypothermia to protect the brain and other vital organs during periods of decreased oxygen delivery is used during cardiac surgery. The beneficial effects of Brain Hypothermia were empirically attributed to its ability to decrease cellular metabolism and thus delay the processes leading to irreversible cell death. Based on this, it
Solid organ transplantation is the therapy of choice for patients with end-organ failure. Despite numerous advances in the field, the number of individuals awaiting solid organ transplantation continues to exceed the supply of organs. One approach to increasing the supply of organs is to maximize donation rates of eligible patients. Family consent rates for donation
Although mannitol remains the mainstay of hyperosmolar therapy, Hypertonic Saline Infusion is an alternative to mannitol. The main theoretical justification for using Hypertonic Saline Infusion stems from the fact that an intact BBB is less permeable to saline than to mannitol. In clinical reports of intracranial hypertension from various causes, HS has been shown to
The principal options for Cerebral vasospasm treatment and treating delayed cerebral ischaemia are haemodynamic augmentation and endovascular therapy. Alternative therapies include intra-aortic counter pulsation (IABC), therapeutic hypothermia dedicated Cerebral vasospasm treatment and barbiturate coma. The concept of haemodynamic augmentation – also referred to as hypertension, hypervolemia, hemodilution or triple-H therapy—in patients with aneurysmal subarachnoid haemorrhage
Oxygen partial pressure decreases to 100 mm Hg up to alveoli. Oxygen tension in venous blood is 40 mm Hg. About one-fifth (20.9%) of air contains oxygen. In the inspired air, oxygen has partial pressure at 1/5 of the atmospheric pressure, i.e., 159 mm Hg. The larger the O2 or CO2 tension difference between the
The neuroprotective effects of Magnesium on Brain have been reported in experimental models of traumatic brain injury, cerebral ischaemia and acute subarachnoid haemorrhage. Magnesium on Brain reduces infarct volume in various animal models of embolic stroke. The mechanisms by which magnesium protects include the reduction of presynaptic release of glutamate, blockade of NMDA receptors, smooth
