Blood Brain Barrier crossing Drugs
The foregoing discussion is in the situation of a normal blood brain barrier about blood brain barrier crossing drugs. In a brain lesion, where the integrity of BBB varies …
Category: Drugs
Effect of barbiturates drugs in cerebral ischaemia
Barbiturates drugs have been the prototype for anaesthetic protection against cerebral ischaemia. The primary mechanism of protection of barbiturates drugs in cerebral ischaemia has been attributed to its ability to …
Oxygenation Capacity
Oxygenation capacity is the volume of oxygen at standard pressure and temperature carried by 100 mL of blood after saturation with room air. Oxygenation capacity includes the oxygen in …
Alveolar partial pressure of oxygen
For the Alveolar partial pressure of oxygen we see, Increasing the inspired concentration (F1) of an anaesthetic agent increases the alveolar concentration (FA). A 75% nitrous oxide (N20) in …
Pharmacological management of pain
The drugs remain the main modality to achieve pharmacological management of pain . Various routes of administration for various drugs have been employed. The quest for an ideal, suitable …
Benzodiazepine equivalence
Among benzodiazepine equivalence , differences in the onset and duration of action are due to their potency, lipid solubility and pharmacokinetics. Benzodiazepine equivalence is used to understand the relative …
Hypoxia Mechanism
Hypoxia mechanism Following phases are included in the Hypoxia mechanism : 1. Anoxic hypoxia—Gas phase. There is inadequate supply of oxygen to the lungs, or the lung is not …
Phenobarbital Status Epilepticus
Phenobarbital status epilepticus that does not respond to first-line ben-zodiazepines (lorazepam or diazepam) or to second-line antiepileptic drugs (phenytoin/fosphenytoin, phenobarbital or valproate) is usually considered refractory and requires more …
Barbiturate Allergy
Incidences of anaphylaxis have been reported after induction with thiopental. The incidence of barbiturate allergy is estimated to be 1 per 30,000 patients. The majority of the patients who …
Propofol Myoclonus
Excitatory events following propofol administration are well described. The pathophysiology of these propofol myoclonus movements is not known. The drug should be used cautiously in patients with movement disorders. …