The sedative midazolam side effects and fluctuations in vital signs were the most frequent findings following parenteral administration of midazolam injection.
These are affected by the lightening or deepening of anesthesia, instrumentation, intubation and use of concomitant drugs.
The more frequently encountered fluctuations in vital signs of midazolam side effects included decreased tidal volume and/or decreased respiratory rate and apnoea, as well as variations in blood pressure and pulse rate.
Other midazolam side effects and adverse reactions occurring at a lower incidence usually are:
Cardiovascular: premature ventricular contractions, bigeminy, vasovagal episode, bradycardia, tachycardia, and nodal rhythm.
Respiratory: laryngospasm, bronchospasm, dyspnoea, shallow respiration, hyperventilation and wheezing.
CNS/Neuromuscuiar: nervousness, restlessness, anxiety, argumentativeness, aggression, insomnia, nightmares; deep sedation, prolonged sedation, oversedation, disorientation, slurred speech, emergence delirium, agitation during emergence, prolonged emergence from anaesthesia, dreaming during emergence; dysphoria, euphoria, anterograde amnesia, lightheadedness, feeling faint; tremors, muscle contractions, twitches and abnormal spontaneous muscular activity, tonic/clonic movements, athetoid movements; ataxia.
Gastrointestinal: acid taste, excessive salivation and retching.
Special senses: blurred vision, diplopia, nystagmus, visual disturbance, difficulty in focusing eyes, pinpoint pupils, cyclic movement of eyelids, ear block and loss of balance.
Dermatological: erythema, rash, pruritus and hives.
Hypersensitivity: allergic reactions, including anaphylactic shock.
Miscellaneous: muscle stiffness, toothache, yawning, cold feeling when drug injected and cool sensation in arm during infusion.
These were the commonly seen midazolam side effects .