Drugs

Propofol Effects

Propofol decreases intraocular pressure and therefore has lot of propofol effects A single low dose bolus of propofol used for sedation before cataract surgery caused a moderate reduction in intraocular pressure with minimal side effects.  Propofol Effect on Coagulation and Immunity System Some of the propofol effects are discussed here. Propofol does not cause significant coagulation

Propofol Effects Read More »

Propofol Contamination

Propofol contamination in an emulsion formulation, has been associated with infective complications. It becomes contaminated once the ampoules have been opened. Propofol contamination supports the growth of all microorganisms. Diphtheroid bacilli and coagulase-negative staphylococci were the most frequent microorganisms. Others are E. coli, S. aureus, and P. aeruginosa. Adding lidocaine, or storing opened ampoules at

Propofol Contamination Read More »

Propofol Bradycardia

Bradycardia and asystole have been observed after induction of anesthesia with propofol. The risk of propofol bradycardia related death during propofol anesthesia has been estimated to be 1.4 in 100,000. Severe, refractory, and fatal bradycardia has been observed with long-term propofol bradycardia infusion. In contrast to thiopentone, propofol apparently lacks central vagolytic activity and may

Propofol Bradycardia Read More »

Propofol Antioxidant

Propofol has a chemical structure similar to that of phenol-based free radical scavengers such as vitamin E, and reduces free radicals. This Propofol antioxidant may directly intervene at the critical phase of reperfusion injury by reducing free radicals, Ca 2+ influx and neutrophil activity. Oxygen leads to the formation of free oxygen radicals which react

Propofol Antioxidant Read More »

Etomidate Injection

The original formulation of Etomidate injection contains propylene glycol as a solvent contributing to a high incidence of pain during IV injection and occasional venous irritation. The newer lipid emulsion formulation is devoid of pain on injection and venous complications such as reddening, swelling, induration; as well as allergic reactions, whereas the incidence of myoclonus

Etomidate Injection Read More »

Barbiturate Therapy

For the Barbiturate therapy , High-dose barbiturates appear to be useful adjuncts in the control of intracranial hypertension refractory to other methods of therapy. Barbiturates decrease ICP by decreasing cerebral blood volume through drug-induced cerebral vascular vasoconstriction and an associated decrease in cerebral blood flow. This therapy in used either as a anti seizure medication

Barbiturate Therapy Read More »

Etomidate Half Life

Etomidate induces loss of consciousness rapidly (5—15 seconds) and recovery occurs in 5 to 15 minutes. The elimination Etomidate half life is 4.6 +1- 2.6 hours and total apparent volume of distribution, 4.5 +/- 2.2 L/kg. The volume of distribution of etomidate half life is large, suggesting considerable tissue uptake. The plasma clearance is 879

Etomidate Half Life Read More »

Phenobarbital Dosage

Phenobarbital dosage include 3 to 5 mg/kg IV, produces rapid induction producing unconsciousness within 30 seconds. Although propofol is becoming the most popular drug for induction of anesthesia for its quick offset from anesthesia, thiopental is still in use due to its low cost in comparison particularly in developing countries. Phenobarbital dosage still remains the

Phenobarbital Dosage Read More »

Scroll to Top