Propofol Effects

Propofol decreases intraocular pressure and therefore has lot of propofol effects A single low dose bolus of propofol used for sedation before cataract surgery caused a moderate reduction in intraocular pressure with minimal side effects.

 Propofol Effect on Coagulation and Immunity System

Some of the propofol effects are discussed here. Propofol does not cause significant coagulation changes or alter platelet function. Propofol causes reticuloendothehal system dysfunction probably due to its solvent intrahipid.

In vitro studies have demonstrated propofol to produce a dose-dependent inhibition of phagocytosis and superoxide anion production during the respiratory burst of polymorphonuclear cells (PMNs).

However, Heine et al. documented that, 4 hours of anaesthesia with propofol did not reduce the phagocytotic. capacity of human blood PMN more than isoflurane anaesthesia.

One of the propofol effects is that Propofol has anti-inflammatory properties, decreasing production of proinflammatory cytokines, altering expression of nitric oxide, and inhibiting neutrophil function.

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