Propofol Contamination

Propofol contamination in an emulsion formulation, has been associated with infective complications. It becomes contaminated once the ampoules have been opened. Propofol contamination supports the growth of all microorganisms.

Diphtheroid bacilli and coagulase-negative staphylococci were the most frequent microorganisms. Others are E. coli, S. aureus, and P. aeruginosa.

Adding lidocaine, or storing opened ampoules at 12-14 degrees C, does not affect the contamination rate, except during the first few hours.

It is advisable to draw propofol aseptically as recommended by manufacturers of propofol, into a syringe in an amount that can be used during one procedure. EDTA added to propofol retards microbial growth.

1 thought on “Propofol Contamination”

  1. 4th of December 1992, I was given prpofol during hysterectomy ,,I was very ill there after ,, now 22 years later I steel have illness that dose not have cure .. Pain in bones , joints, headache’s . constant nosier , , fevers ,, limited activity’s ,, small activity’s with pain … I fill depress from long term pain ..

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