Drugs

Common benzodiazepines

Among the common benzodiazepines that are used in anesthesia today are three: namely diazepam, midazolam and lorazepam. Benzodiazepines produce varying degree of anxiolysis, sedation, anticonvulsant actions and anterograde amnesia. Benzodiazepines also produce some degree of skeletal muscle relaxation but that is not sufficient for surgical procedures; and they also do not decrease the dose requirements

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Propofol half life

It is rapidly distributed in the body with a propofol half life of only around 2 mm and has an efficient hepatic and extra hepatic clearance. Because the total body clearance may exceed liver blood flow, an extrahepatic metabolism or extrarenal elimination has been suggested. Hepatic metabolism is rapid and extensive, resulting in inactive, water-soluble

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Phenobarbital Schedule

The Phenobarbital schedule is listed here. The long-term administration of high doses of thiopental is associated with an increased incidence of nosocomial infections and associated mortality. Barbiturate coma may cause reversible leucopenia and an increased infection rate. Long-term administration of thiopental may also promote reversible antibiotic-induced bone marrow suppression. Thiopentone depresses T-lymphocyte function. Loop et

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