Propofol uses includes that, it does not trigger malignant hyperthermia in susceptible patients or experimental animals.
The major Propofol uses are its use as Anesthetic agent or as a sedative. It is the drug most commonly used for induction of anesthesia. It can also be used for maintenance of anesthesia when it is ran as an infusion, like in total intravenous anesthesia.
In contrast to malignant hyperthermia triggering inhalation anesthetics, propofol does not stimulate malignant hyperthermia susceptible or normal ryanodine receptor channel activity, even at> 100 times clinical concentrations.
You may be familiar that some propofol uses are implemented without any restriction in all cases of asymptomatic hepatic porphyria, as a bolus injection for induction and maintenance of anesthesia and as a continuous infusion to produce anesthesia of short and medium duration.
However, safety of propofol in case of symptomatic hepatic porphyria remains inconclusive. Preference has to be given to neuroleptanalgesia, benzodiazepines and muscle relaxants. If propofol is to be used, treatment with haematin should be readily available.
Some of the propofol uses are that, it is being used with some success in treating postoperative laryngospasm and for tracheal intubation without muscle relaxants. Due to its bronchodilating property it can be used for induction in asthmatic patients.