Despite the rapid clearance of propofol pharmacokinetics by metabolism, there is no evidence of impaired elimination in patients with cirrhosis of the liver.
Chronic alcoholism does not change the propofol pharmacokinetics significantly. Extrahepatic elimination of propofol occurs during the anhepatic phase of orthotopic liver transplantation.
Renal dysfunction does not influence the clearance of propofol. Patients older than 60 years of age exhibit a decreased rate of plasma clearance of propofol compared with younger adults and require dose modification.
The rapid clearance of propofol confirms this drug can be administered as a continuous infusion without an excessive cumulative effect.
Propofol pharmacokinetics readily crosses the placenta; however, it is rapidly cleared from the neonatal circulation.
The amount of propofol excreted into milk within 24 hours of induction of anesthesia dose not mandate discontinuation of breastfeeding.
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