Etomidate pharmacology is studied using following points. In etomidate pharmacology we find that Etomidate is a potent, direct cerebral vasoconstrictor. It decreases cerebral blood flow and CMRO2 in an independent manner. The cerebral metabolic effects of etomidate are secondary to its effect on neuronal function. As a result, previously increase ICP is lowered by etomidate […]
Etomidate sedation infusion can be used as a suitable alternative for neuroanesthesia when nitrous oxide is contraindicated. Etomidate sedation (100 micrograms/kg/ minute) has been used as a part of total intravenous anesthetic technique with a mean recovery time of about 10 minutes. The infusion is associated with minimal incidences of side effects such as thrombophiebitis
Etomidate dosage may be viewed as an alternative to propofol or barbiturates for the IV induction of anaesthesia, especially in the presence of an unstable cardiovascular system. After a standard induction dose of 0.2 to 0.4 mg/kg IV, the onset of unconsciousness occurs within one arm-to-brain circulation time. Involuntary myoclonic movements are common during the
Propofol related infusion syndrome is a rare complication firstly reported in paediatric patients and also observed in adults, produced due to prolonged (>48 h) high doses of propofol (>66 mcg/kg/min) intravenous infusion. Even short-term propofol related infusion syndrome for surgical anaesthesia have been associated with development of metabolic acidosis. Propofol related infusion syndrome is characterized
Propofol at common clinical concentrations-is potent ventilatory depressant and therefore it is sometimes common with the name propofol respiratory depression . The Propofol respiratory depression of ventilation is dose dependent. After induction of anesthesia with propofol apnoea occurs in 25% to 35% of patients which may persist till 3 minutes. It reduces tidal volume (by
The effect of propofol on blood pressure is that it decreases systemic blood pressure. This decrease in propofol blood pressure is often accompanied by corresponding changes in cardiac output and systemic vascular resistance. Propofol decreases afterload more than thiopental and thus reduces systemic arterial pressure more than thiopental. Propofol preferentially decreases SVR without a significant
Propofol is a global central nervous system depressant. Propofol general anesthesia decreases cerebral metabolic rate for oxygen (CMRO2), cerebral blood flow (CBF), and intracranial pressure (ICP). Decrease in CBF is more than sevoflurane. Propofol is a cerebral vasoconstrictor and thus lowers ICP. Propofol decreases ICP greater than isoflurane and sevoflurane while cerebral perfusion pressure is
Propofol uses includes that, it does not trigger malignant hyperthermia in susceptible patients or experimental animals. The major Propofol uses are its use as Anesthetic agent or as a sedative. It is the drug most commonly used for induction of anesthesia. It can also be used for maintenance of anesthesia when it is ran as
At sub anesthetic doses, propofol anticonvulsant has been effectively used to suppress seizures during refractory status epilepticus, a mechanism, in part, attributed to the inhibition of neuronal sodium channels. It is effective in most patients, and the side effects are infrequent, of minor severity, and fully reversible. However, high doses of propofol may be necessary
Subhypnotic doses of IV like Propofol 10 mg have been used to treat pruritus caused by neuraxial opioids. However, this beneficial effect has not been achieved in other studies. Propofol has been shown to possess antipruritic effect. Subhypnotic doses of propofol may be effective for the short-term symptomatic relief of pruritus associated with liver disease. Such
