As with other volatile agents desflurane depresses the respiratory system. Desflurane respiratory effects are quite different. There is a dose-dependent decrease in tidal volume, decreased minute volume and CO2 retention, and an increase in respiratory rate. The ventilatory response to CO2 is reduced. One of the desflurane respiratory effects is that, the desflurane is extremely […]
Desflurane undergoes very little desflurane metabolism because of low blood/gas and low blood/tissue solubility. However, 0.02% is metabolized during desflurane metabolism with the production of trifluoroacetic acid which may interact with hepatic proteins and induce an immune response in susceptible patients. Previous exposure to halothane may produce antibodies. In desflurane metabolism , the elimination is almost exclusively by
Desflurane muscle relaxation chemical depresses the neuromuscular junction, it decreases the force of contraction of muscles and increases fade. Endotracheal intubation is possible. There is a potentiation of nondepolarizing muscle relaxants similar to isoflurane. There have been no reports of malignant hyperthermia in man but has been seen in animals. It is advisable to avoid
There is rapid desflurane induction of anesthesia because of low solubility in blood, but a mask induction may produce coughing, breath holding, secretions and desaturation. Also the high initial percentage of desflurane induction may cause tachycardia and hypertension due to sympathetic effects. It is not recommended for inhalation induction. Recovery from desflurane induction is faster
The kinetics of the anaesthetic agents during recovery from inhalant anesthesia are a reversal of the mechanism seen during induction. On cessation of anaesthetic agent, the fall in alveolar concentration is immediate. The gradient between venous blood and alveoli drives the anaesthetic into the alveoli. In terms of recovery from inhalant anesthesia , the poorly
Chloroform anesthesia is prepared from chloroform chemical formula and is a potent, pleasant, non-irritant anaesthetic agent, very popular in the early days of anaesthesia. Physical properties of Chloroform chemical formula are that, it is colourless, sweet odour, non flammable, bp 6 1°C, VP 80mm Hg, blood/gas coefficient 10.3, oil/gas 394, MAC 0.62, metabolism 50% to
Halothane Anesthesia is an alkane, halogenated hydrocarbon introduced in 1256. (M Johnston, UK). Physical Properties: Halothane Anesthesia is colorless, sweet smelling, nonirritating, bp 50 degrees C, VP 243 mm Hg, blood/gas 2.5, oil/gas 224, metabolism 20—40%, MAC in 02 ofQ7 /o and 0.29% with N20. It is relat Istable, decopcs on exposure tq.ajr, hence stored
There is very little airway irritation, hence used for inhalation induction especially in children. One of the halothane respiratory effects is that it is a potent respiratory depressant, reduces tidal volume and alveolar minute ventilation. The ventilatory response to raised Paco2 and reduced Pao, may be reduced due to depression of peripheral chemoreceptors in the
Halothane cardiovascular effect plays a critical role. The main haemodynamic effect is a reduction in blood pressure secondary to a fall in cardiac output, reduced cardiac contractility and stroke volume, due to alterations in Ca-metabolism and a reduction in intracellular calcium. So, the coronary blood flow is reduced. The heart rate often falls due to
The MAC of halothane pharmacokinetics varies from 1.08 in neonates to 0.64 in the elderly, Addition of N20 in adults reduces MAC to 0.29%. The distribution of halothane is to lungs, VRG organs, muscle, fat around VRG organs and finally peripheral fat. Excretion is primarily through the lungs in a reverse manner. Halothane Pharmacokinetics undergoes
