Miller’s Anesthesia says the following about desflurane respiratory effects –
Comparison of the effect of different volatile anesthetics at equivalent concentrations on total pulmonary resistance. At 1 minimum alveolar concentration (MAC), only desflurane significantly increased pulmonary resistance when compared with isoflurane and sevoflurane.
At 1.5 and 2 MAC, sevoflurane significantly increased total pulmonary resistance when compared with isoflurane, whereas desflurane caused a more pronounced increase than the other two agents did.
Increased pulmonary resistance in comparison to sevoflurane and isoflurane; increased pulmonary resistance in comparison to isoflurane.
In another place it says about desflurane respiratory effects –
The bronchoconstricting effects of low inhaled concentrations of carbon dioxide were attenuated by inhaled but not by intravenous halothane, thus suggesting a direct action on airway musculature or local neural reflex arcs rather than centrally controlled reflex pathways.
Halothane-, isoflurane-, sevoflurane-, and desflurane-induced dilatation of distal bronchial segments partially depends on the presence of bronchial epithelium.