Anesthesia

Metabolism of volatile anesthetics

Metabolism of volatile anesthetics is discussed here. Once thought to be chemically inert, inhalation agents, especially the older ones, undergo significant metabolism, bio-transformation and breakdown to potentially toxic intermediates. This process is affected by age, disease, drug interaction and genetics. Inhalation agents are administered in great excess of the amount metabolized unlike other drugs. For […]

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Toxicity of inhalational anesthesia

Hepatotoxicily has been seen since the introduction of anesthetics. Chloroform and trichloroethylene have been abandoned for toxicity of inhalational anesthesia . The toxicity may be intrinsic as seen with Chloroform or acetaminophen. Halothane exhibits an allergic or hypersensitivity reaction to a drug metabolite protein. The toxicity of inhalational anesthesia with the incidence of liver injury is Halothane> Isoflurane

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