The MAC of halothane pharmacokinetics varies from 1.08 in neonates to 0.64 in the elderly, Addition of N20 in adults reduces MAC to 0.29%. The distribution of halothane is to lungs, VRG organs, muscle, fat around VRG organs and finally peripheral fat. Excretion is primarily through the lungs in a reverse manner. Halothane Pharmacokinetics undergoes
Hepatotoxicily has been seen since the introduction of anesthetics. Chloroform and trichloroethylene have been abandoned for toxicity of inhalational anesthesia . The toxicity may be intrinsic as seen with Chloroform or acetaminophen. Halothane exhibits an allergic or hypersensitivity reaction to a drug metabolite protein. The toxicity of inhalational anesthesia with the incidence of liver injury is Halothane> Isoflurane
