Sevoflurane metabolic effects are seen when approximately 5% of the dose is metabolized by the liver, catalyzed by cytochrome P450 (2E1) enzyme. While Sevoflurane metabolic effects are studied we see that, it is broken down to hexafluoro isopropanol (HFIP) and fluoride ions. Hexafluoro isopropanol is conjugated with glucuronic acid to form HFIP glucuronide and excreted […]
Understanding Granisetron’s Use in Anesthesia for Nausea and Vomiting When undergoing anesthesia, one of the common side effects that patients may experience is nausea and vomiting. These unpleasant symptoms can not only cause discomfort but also delay the recovery process. To alleviate this, healthcare professionals may administer medications like granisetron. In this article, we will
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Below is an answer to the simple question what is sleep? What is Sleep? Physiologically, sleep is regarded as absence of wakefulness, where the responses to environmental stimuli are greatly reduced. But, in fact, it is an active state, related to definite anatomic structures as well to specific biogenic amines. Yet, its exact mechanism is
Nitrous oxide induction agent is a weak anaesthetic agent and not suitable as a sole anaesthetic agent. Nitrous oxide induction agent is used to hasten inhalational induction of anaesthesia due to its “concentration and second gas effects”. There is a smooth and pleasant induction. The recovery from anaesthesia is rapid; however, a “diffusion hypoxia”
Some of the Sevoflurane respiratory effects include that there is no irritation to the airway, least among inhalation agents, this makes it suitable for inhalational induction, the low blood/gas solubility aids faster induction. Sevoflurane respiratory effects include respiratory depression, reduces minute ventilation, tidal volume and ventilatory response to CO2. Sevoflurane abolishes hypoxic pulmonary vasoconstriction in
Posterior fossa is a tight infratentorial compartment which harbors vital centers like cerebellum, pons and medulla. Anesthesia for Posterior Fossa Surgery is employed in carious types of space-occupying lesions, i.e., cerebellar tumours, cerebellopontine angle lesions, medulloblastoma, brainstem glioma occur in this area. The patients with posterior fossa tumor presents with features of raised intracranial pressure, brain
One of the most dreaded Halothane Complications is hepatic injury. There are two types, the first which is a transient sub clinical type with increases in liver enzymes. Halothane Complications may occur due to decreased hepatic blood flow and reductive biotransformation. Secondly, fatal hepatic necrosis may occur up to one month after exposure. The National Halothane
McNarry and Goldhill compared ACDU Scale (Alert, Confused, Drowsy, Unresponsive) and AVPU scale (Alert, responds to Voice, responds to Pain, Unresponsive) by the American college of surgeons with GCS scale for neurological assessment of critically ill ward patients. Just like GCS the ACDS Scale is a method to assess the neurological status and level of
Wong baker pain assessment tool is used in the patients who do not have appropriate cognitive level to use a number scale, like lay persons or children. The patient then points out to face best represents how he/she is feeling at that point of time. The patient must be explained correlation between each face and
The reduced cerebrovascular resistance at the site of Arteriovenous Malformations AVMs lead to an increase in blood flow to this area and the formation of a lower resistance shunt along with peri-infarction oedema. They usually represent a high-flow and low-resistance shunts with systemic arterial pressure more than the vascular intramural pressure ; so, rupture does
