There are several disadvantages of disadvantages of carbon dioxide : • High concentration causes narcosis. • It increases the cerebral blood flow and intracranial pressure. • It stimulates sympathetic nervous system, which may be dangerous in some patients already having systemic hypertension or myocardial ischaemia. • It sensitizes myocardium to externally administered catecholamines. • It
Pethidine injection is a synthetic morphine like analgesic. this opioid medication has about one tenth as powerful compared to morphine. This drug has sedative and tranquilizing effects also. It may cause euphoria and sleepiness. Unlike morphine it tends to relax smooth muscles and thus relieves most types of pain associated with plain muscle spasm. But
Malignant hyperthermia (MH) is a hypermetabolic disorder of skeletal muscle that is triggered in susceptible individuals by several inhalation anesthetic agents (sevoflurane, desflurane, isoflurane, halothane, enflurane, and methoxyflurane) and succinylcholine. These anesthetic triggers cause intracellular hypercalcemia in skeletal muscle by decreasing the uptake of calcium by the sarcoplasmic reticulum. The intracellular hypercalcemia activates metabolic pathways
Some of the Sevoflurane respiratory effects include that there is no irritation to the airway, least among inhalation agents, this makes it suitable for inhalational induction, the low blood/gas solubility aids faster induction. Sevoflurane respiratory effects include respiratory depression, reduces minute ventilation, tidal volume and ventilatory response to CO2. Sevoflurane abolishes hypoxic pulmonary vasoconstriction in
Neuroleptanalgesia Neuroleptanalgesia is method of IV anesthesia which combines at neuroleptic drug with opioid analgesic drug. The most favored combination is neuroleptic droperidol and the analgesic fentanyl. The combination used neuroleptanalgesia induces state which is different from usual general anesthesia. Because the patient is awake during surgery and is cooperative during the operative and surgical
Enflurane is not a very commonly used agent in the developing counties although its usage is on in America. It is a newer inhalational agent like that of halothane. Enflurane is halogenated ether. Enflurane Physical Properties : It is a Colorless gas. It has ethereal odor. It is Non inflammable at clinical concentration but inflammable
Isoflurane volatile anesthetic is a halogenated methyl ethyl ether, which is a racemic mixture. It is very stable at room temperature, soda-lime and UV light. It has an ethereal odour and is irritating to the respiratory tract and not epileptiform. Metabolism 0.2% Physical properties: Isoflurane volatile anesthetic has a bp of 48.5°C similar to halothane,
Halothane Malignant hyperthermia syndrome may be triggered by halothane, it is an autosomal dominant inherited condition. There is a massive release of intracellular calcium from the sarcoplasm of the muscle. An increased metabolism results in rise in temperature of 2°C per hour, severe acidzsis, rhabdomyolysis, with associated hyperkalaemia. Mortality is 70%. Treatment is by active
In normal Blood Brain Barrier functions the effective pore size of cerebral capillaries is 7-9 A°. This small pore size does not allow movement of small ions, i.e, Na, K and C1. Therefore, the fluid movement across the Blood Brain Barrier Functions is determined by the ‘total’ osmotic gradient, generated both by large molecules and
Entotracheal intubation is a life saving technique used frequently in emergencies and in operation theaters. Hence, the Intubation Indications need to be known to all doctors. The Major intubation indications are as follows: For ventilation of the patient: When the patient is unconscious or in a state of apnoea, where he is not breathing, Intubation
