Missed injuries, commonly referred to as the trauma surgeon’s nemesis, are an expected occurrence in the management of multiply injured patients. The definition of a missed injury is institution specific. Generally speaking, however, a missed injury is an injury identified at some defined time after the initial assessment. Missed injuries are not frequently life-threatening. However, […]
Fetal distress can be caused by a host of factors; most notably, hypoxemia and hypovolemia are dangerous for the viable fetus. It is not uncommon for a pregnant patient to be affected by critical illness. Examples of nonobstetric maladies that lead to intensive care unit admission among pregnant women are hematologic issues (venous thromboembolism and pulmonary embolus,
Many drugs are metabolized to active metabolites. This is usually carried out by the liver in the form of reductions, oxidations, and the addition of methyl, acetyl, and other groups. watchesbest.org While metabolites are usually a fraction as potent as the parent compound, in some situations they may be more potent and may accumulate to
Signs and Symptoms of hemolytic reaction An acute hemolytic reaction occurs when immunologic incompatibility following transfusion, between the donor and the recipient results in lysis of red blood cells. Most hemolytic reactions are due to the transfusion of ABO-incompatible packed red blood cells secondary to clerical or system errors. The severity of the reaction is
Hyperbaric Oxygen means delivering the oxygen above atmospheric pressure which is 760 mmHg (or 1 atm). Special hyperbaric chambers are made for providing hyperbaric Oxygen, which are very expensive. Hyperbaric Oxygen Uses A. Poisonings: Carbon monoxide poisoning (half life of CO at 1 atm is 214 minutes which can be reduced to 19 minutes at
Mechanism of Action of Milrinone Milrinone is a selective inhibitor of type III cyclic adenosine monophosphate (cAMP) phosphodiesterase isoenzyme in cardiac and vascular smooth muscle. Its inhibitory action on phosphodiesterase results in increased cAMP levels, which in turn increases contractility in cardiac muscle and stimulates vasodilatation in blood vessels. This causes an increase in cardiac
Cerebral ischaemia or hypoxia may occur as a consequence of shock, vascular stenosis or occlusion, vasospasm, neurotrauma and cardiac arrest. Strategies to protect the brain i.e Cerebral protection from ischemic/hypoxic insults are based on the understanding of pathophysiological processes that follow ischemia/hypoxia to result in neuronal death. Neurologic morbidity is common in those patients experiencing
Acute myopathy has been increasingly recognized as a significant complication of patients cared for in the intensive care unit (ICU). The term critical illness myopathy (CIM) or ICU Myopathy is now used to describe a general syndrome of muscle dysfunction occurring in the critically ill patient, with subtypes of CIM also being defined. The major
Little substantial human data exists concerning the impact of fluids on the brain, which may guide rational IV Fluid Replacement in neurosurgical patients. Therefore, recommendations arise from known factors that influence water movement into the brain. IV Fluid Replacement in neurosurgical patients can alter three properties of the blood, viz., osmolality, colloid oncotic pressure and
Although mannitol remains the mainstay of hyperosmolar therapy, Hypertonic Saline Infusion is an alternative to mannitol. The main theoretical justification for using Hypertonic Saline Infusion stems from the fact that an intact BBB is less permeable to saline than to mannitol. In clinical reports of intracranial hypertension from various causes, HS has been shown to
