Strategies to protect the brain i.e Cerebral protection from ischemic/hypoxic insults are based on the understanding of pathophysiological processes that follow ischemia/hypoxia to result in neuronal death.
Neurologic morbidity is common in those patients experiencing global cerebral ischemia as a consequence of cardiac arrest and is thought to be related to the generation of free radicals and cellular injury on reperfusion of the ischemic brain.
Cerebral protection implies improved outcome as evidence by electrophysiologic, metabolic or histologic indexes of recovery.
Although the therapeutic Cerebral protection value of induced moderate hypothermia has been disappointing in both traumatic brain injury and SAH, its efficacy in improving neurologic outcome has been demonstrated in patients who suffered global hypoxia secondary to ventricular fibrillation.
Two studies reported improved neurologic outcome and reduced mortality in patients with ventricular fibrillation who were resuscitated but remained in coma and immediately treated with mild hypothermia in the 32° to 34°C range. These results have been confirmed in a wider population, and 12 to 24 hours of mild hypothermia is now recommended treatment for all post–cardiac arrest patients with neurologic dysfunction.
Whereas initial studies induced hypothermia using cooled intravenous solutions, more sophisticated methods/devices have since been introduced. These include noninvasive methods such as forced air cooling with limb and trunk blankets, topical adhesive cooling pads, as well as invasive methods deploying intravascular heat exchange catheters. Water-cooled adhesive pads connected to heat exchange units are the most commonly used methods at present.
Some clinicians consider the use of somatosensory evoked potentials (particularly the N20 and N70 latencies) to be helpful for Cerebral protection in the prognosis of coma after cardiac arrest.
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Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346:549-556.
Nolan JP, Morley PT, Hoek TL, Hickey RW: Therapeutic hypothermia after cardiac arrest: An advisory statement by the Advancement Life support Task Force of the International Liaison committee on. Resuscitation. Resuscitation 2003; 57:231-235.
Madl C, Kramer L, Domanovits H, et al: Improved outcome prediction in unconscious cardiac arrest survivors with sensory evoked potentials compared with clinical assessment. Crit Care Med 2000; 28:721-726.