Use of midazolam in seizures has been used intravenously to treat acute attack of seizure effectively.
Recent studies proved its usefulness through oral and intranasal route to control acute seizure attack particularly in children.
The efficacy of intranasal and oral midazolam in seizures in hospitalized patients was similar to, and even higher than, that of intravenous or rectal diazepam, with a similar speed of action and safety when dealing with seizures.
Aerosols containing a solution of midazolam in cyclodextrin, accomplish a greater concentration with a pH that is less acidic and more suitable for nasal application than commonly available parenteral preparation which is more irritant due to its acidic pH.