Midazolam oral dose

A syrup is effective for producing sedation and anxiolysis at a Midazolam oral dose of 0.25 mg/kg with minimal effect on ventilation even when administered at doses as large as 1 mg/kg.

Midazolam oral is the most commonly used oral preoperative medication for children.

Midazolam oral dose which is, 0.5 mg/kg given orally 30 minutes before induction of anesthesia, provides reliable sedation and anxiolysis in children without producing delayed awakening.

Midazolam produces significant retrograde amnesia at dosage of 0.5 mg/ kg even if administered 10 minutes before surgery.

Midazolam when given oral is absorbed rapidly after intramuscular (0.1 to 0.15 mg/kg, maximum of 7.5 mg), oral (0.25 to 1.0 mg/kg, maximum of 20 mg), rectal (0.75 to 1.0 mg/kg, maximum of 20 mg), nasal (0.2 mg/kg), or sublingual (0.2 mg/kg) administration.

More recently, an oral formulation of midazolam has been used primarily for oral premedication in pediatric patients .

Midazolam oral dose is 0.5 mg/kg, and one preparation is from the Roche parenteral formulation of 0.5 mg/mL (Roche Laboratories, Inc, Nutley, NJ) mixed in with 10 mg/kg of oral acetaminophen (McNeil-PPC, Inc, Fort Washington, PA).

Other preparations have been developed, including strawberry-flavored glucose (pH 4.5) prepared by the pharmacy, which is stable for 8 weeks. The Midazolam oral dose of 0.5-mg/kg  is rapid-acting, providing reliable amnesia within 10 minutes and rendering children effectively sedated for anesthesia induction.

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