Etomidate Pharmacokinetics

The etomidate pharmacokinetics is altered in the elderly, with a decrease in initial distribution volume and clearance (a decrease of 2 mL/min/kg every decade).

Compared to normal patients, the cirrhotic patients have normal clearance rates, suggesting that cirrhotic patients metabolize etomidate normally, but the distribution volume and elimination half-life were twice as great.

A 30% higher etomidate pharmacokinetics bolus dosage is required in children than in adults to achieve similar plasma concentrations, due to a higher initial volume of distribution.

In comparison to adults the higher clearance suggests higher maintenance dose requirements in children. This was in brief about the pharmacokinetics of etomidate.

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