Here we study about the physical effects of barbiturates . In normovolemic subjects, thiopental, 4-5 mg/kg IV, produces a transient mild to moderate decrease in blood pressure with a compensatory increase in heart rate. However, bradycardia and junctional rhythm may occur with thiopentone. This dose of thiopental produces minimal to no evidence of myocardial depression. […]
The pharmacokinetics of inhaled anesthetics are explained here with detail • Absorption of agent from alveoli to blood • Distribution in the body • Metabolism (liver) • Elimination (lungs mainly) Uptake and Distribution The pharmacokinetics of inhaled anesthetics depends upon: (1) Respiratory uptake, (2) Alveolar ventilation, (3) The partial pressure of the agent in the
It is rapidly distributed in the body with a propofol half life of only around 2 mm and has an efficient hepatic and extra hepatic clearance. Because the total body clearance may exceed liver blood flow, an extrahepatic metabolism or extrarenal elimination has been suggested. Hepatic metabolism is rapid and extensive, resulting in inactive, water-soluble
Etomidate shortens the onset time of the neuromuscular block with vecuronium. This etomidate drug interactions enhances the bradycardia induced by vecuronium. Miller’s anesthesia says the following about etomidate drug interactions – The specific endocrine effects manifested by etomidate are a dose-dependent reversible inhibition of the enzyme 11β-hydroxylase, which converts 11-deoxycortisol to cortisol, and a relatively minor
Propofol is known to possess direct antiemetic effects. Propofol antiemetic use for induction and maintenance of anesthesia has been shown to be associated with a lower incidence of postoperative nausea and vomiting (PONV) when compared to any other anesthetic drug or technique. It has been shown that total intravenous anaesthesia (TIVA) with propofol for anesthesia
The respiratory effects of Ketamine bronchodilation are noticeable, mainly involving bronchodilation, which is mainly observed in asthmatic patients. Supposedly, Ketamine bronchodilation relaxes the bronchiolar musculature and prevents the bronchoconstriction induced by histamine, which would be an obvious advantage for asthmatic patients. The bronchodilatory activity is as effective as halothane or enflurane in preventing experimentally-induced Ketamine
Propofol related infusion syndrome is a rare complication firstly reported in paediatric patients and also observed in adults, produced due to prolonged (>48 h) high doses of propofol (>66 mcg/kg/min) intravenous infusion. Even short-term propofol related infusion syndrome for surgical anaesthesia have been associated with development of metabolic acidosis. Propofol related infusion syndrome is characterized
Effects of Barbiturates on the body are listed here. Thiopentone decreases the tidal volume and the effect on respiratory rate is biphasic ranging from tachypnea during light anesthesia to a progressive slowing of respiration with deepening anesthesia. However, like propofol, functional residual capacity is not reduced by thiopentone. Effects of Barbiturates on the body administered
The midazolam dose must be carefully individualized. In elderly and debilitated patients, lower doses are required. The midazolam dose should further be adjusted according to the type and amount of premedication used. Excess doses or rapid IV administration may result in respiratory depression and/or arrest, particularly in elderly or debilitated patients. For IM use, midazolam
Acupuncture physiotherapy pain reduction technique is an ancient Chinese modality used for various chronic painful conditions, in addition to non pain related problems like acute asthma, chronic sinusitis, etc. The human body has a life force or energy flowing — Chi. This life force is flowing through various channels — Meridians. The life force (Chi)
