Midazolam pediatric dose loading dose may be followed by a continuous IV infusion to maintain the effect. IV loading doses should not be used in neonates. Continuous IV infusion for sedation in critical care settings is important in pediatric patients. To initiate sedation using midazolam, an IV loading dose of 0.05 to 0.2 mg/kg administered […]
The most significant Methodone feature is its exactly identical pharmacodynamics and methodone mechanism of action as that of morphine in equipotent (equianalgesic) doses. Methodone is an agonist with diphenyl structure (2 phenyl rings at the center). The psychological behaviour of methadone addiction is not as markedly abnormal as that of other pure agonists like heroin,
The most commonly used barbiturate is pentobarbital. Induced coma with use of barbiturates like thiopentone sodium or pentothal is called barbiturate coma or pentobarbital coma . High-dose barbiturates have been used for more than 60 years in critically ill neurologic patients. The most common application has been to lower elevated intracranial pressure (ICP) in patients
Use of midazolam in seizures has been used intravenously to treat acute attack of seizure effectively. Recent studies proved its usefulness through oral and intranasal route to control acute seizure attack particularly in children. The efficacy of intranasal and oral midazolam in seizures in hospitalized patients was similar to, and even higher than, that of
Diazepam IV is a highly lipid-soluble benzodiazepine with a more prolonged duration of action compared with midazolam. Diazepam IV is dissolved in organic solvents (propylene glycol, sodium benzoate) because it is insoluble in water. Dilution with water or saline causes cloudiness but does not alter the potency of the drug. Injection by either the IM
Despite the rapid clearance of propofol pharmacokinetics by metabolism, there is no evidence of impaired elimination in patients with cirrhosis of the liver. Chronic alcoholism does not change the propofol pharmacokinetics significantly. Extrahepatic elimination of propofol occurs during the anhepatic phase of orthotopic liver transplantation. Renal dysfunction does not influence the clearance of propofol. Patients
Depending upon mechanism of nsaid action involved the drugs can be specifically used to achieve the desired effects. The NSAIDs have been proven to block the synthesis of prostaglandins by inhibition of the enzyme cyclo oxygenase. Cyclo-oxygenase (prostaglandin synthetase) is the enzyme involved in the cell membrane injury related destruction of phospholipids to arachidonic acid,
The versed side effects related to Respiratory are respiratory arrest, respiratory failure, apnoea, hypoxia, oxygen desaturation. Danger of respiratory disorders may increase when midazolam is administered with opioids. Therefore, the dosage of both agents should be reduced. Limited information is available from published literature regarding the use of midazolam in paediatric patients. However, based on
Acupuncture physiotherapy pain reduction technique is an ancient Chinese modality used for various chronic painful conditions, in addition to non pain related problems like acute asthma, chronic sinusitis, etc. The human body has a life force or energy flowing — Chi. This life force is flowing through various channels — Meridians. The life force (Chi)
Propofol is a global central nervous system depressant. Propofol general anesthesia decreases cerebral metabolic rate for oxygen (CMRO2), cerebral blood flow (CBF), and intracranial pressure (ICP). Decrease in CBF is more than sevoflurane. Propofol is a cerebral vasoconstrictor and thus lowers ICP. Propofol decreases ICP greater than isoflurane and sevoflurane while cerebral perfusion pressure is
