Oxygenation capacity is the volume of oxygen at standard pressure and temperature carried by 100 mL of blood after saturation with room air. Oxygenation capacity includes the oxygen in combination with haemoglobin (1.39 mL/g) and oxygen in solution in plasma (0.3 mL). It should also be mentioned that most of the oxygen that dissolves in […]
For the Alveolar partial pressure of oxygen we see, Increasing the inspired concentration (F1) of an anesthetic agent increases the alveolar concentration (FA). A 75% nitrous oxide (N20) in oxygen mixture increases the FI/FA ratio of N2O. The amount of nitrous oxide absorbed will be greater than the nitrogen given out in the alveoli, hence
The drugs remain the main modality to achieve pharmacological management of pain . Various routes of administration for various drugs have been employed. The quest for an ideal, suitable analgesic continues. Conventionally three classes of drugs are employed to achieve various degrees of analgesia in pharmacological management of pain : 1. Opioids: For a long time
Among benzodiazepine equivalence , differences in the onset and duration of action are due to their potency, lipid solubility and pharmacokinetics. Benzodiazepine equivalence is used to understand the relative differences in the action and effects of the different types of benzodiazepines. All benzodiazepines are highly lipid soluble and are highly bound to plasma proteins, especially
Hypoxia mechanism Following phases are included in the Hypoxia mechanism : 1. Anoxic hypoxia—Gas phase. There is inadequate supply of oxygen to the lungs, or the lung is not functioning properly. 2. Anemic hypoxia—Fluid hypoxia (phase). There is a decrease in the oxygen carrying capacity of the blood. 3. Stagnant hypoxia—Fluid phase. There is decreases
Phenobarbital status epilepticus that does not respond to first-line benzodiazepines (lorazepam or diazepam) or to second-line antiepileptic drugs (phenytoin/fosphenytoin, phenobarbital or valproate) is usually considered refractory and requires more aggressive treatment. Barbiturate anaesthetics, such as pentobarbital and thiopental sodium, are the most frequently used agents and are highly effective for refractory GCSE both in children
Incidences of anaphylaxis have been reported after induction with thiopental. The incidence of barbiturate allergy is estimated to be 1 per 30,000 patients. The majority of the patients who suffer from anaphylaxis due to barbiturate allergy also possess history of chronic allergy. Barbiturate Allergic reactions include urticaria, angioneurotic edema, other skin reactions, agranulocytosis and thrombocytopenic
Excitatory events following propofol administration are well described. The pathophysiology of these propofol myoclonus movements is not known. The drug should be used cautiously in patients with movement disorders. Miller’s anesthesia says the following about Propofol Myoclonus – Induction of anesthesia with propofol is associated with several side effects, including pain on injection, propofol myoclonus , apnea,
Etomidate shortens the onset time of the neuromuscular block with vecuronium. This etomidate drug interactions enhances the bradycardia induced by vecuronium. Miller’s anesthesia says the following about etomidate drug interactions – The specific endocrine effects manifested by etomidate are a dose-dependent reversible inhibition of the enzyme 11β-hydroxylase, which converts 11-deoxycortisol to cortisol, and a relatively minor
Etomidate metabolism is rapidly metabolized by hydrolysis of the ethyl ester side chain to its carboxylic acid ester, resulting in a water-soluble, pharmacologically inactive compound. Hepatic microsomal enzymes and plasma esterases are responsible for this hydrolysis. Hydrolysis is nearly complete, as evidenced by recovery of < 3% of an administered dose of etomidate metabolism as
