Ketamine receptors have GABAA receptor agonistic properties. Subanaesthetic doses of Ketamine receptors inhibits tonic convulsions induced by the GABAA receptor antagonist bicuculline. The GABAA receptor agonist, muscimol, potentiates ketamin induced anesthesia whereas, bicuculline antagonizes it. Opioid Receptors : Ketamine receptors has been reported to interact with opioid receptors in clinically relevant concentration. Other studies have suggested […]
Mechanism of Action of Milrinone Milrinone is a selective inhibitor of type III cyclic adenosine monophosphate (cAMP) phosphodiesterase isoenzyme in cardiac and vascular smooth muscle. Its inhibitory action on phosphodiesterase results in increased cAMP levels, which in turn increases contractility in cardiac muscle and stimulates vasodilatation in blood vessels. This causes an increase in cardiac
Hyperbaric oxygen therapy is currently used in various clinical treatment regimens like for treating carbon monoxide poisoning. These include decompression sickness, carbon monoxide poisoning, cyanide poisoning, gas embolus, gas gangrene, resistant anaerobic infections, and threatened split-thickness skin grafts. The mechanism of action in treating carbon monoxide poisoning purportedly involves increasing tissue oxygenation, which increases collagen
Heterotopic ossification may occur following head or spinal cord trauma, burns, or major surgery on the musculoskeletal system. A heterotrophic bone may cause severe physical impairment by surrounding a joint such as the hip or the elbow and fixing the joint in a nonfunctional position (i.e., contracture). Heterotopic ossification is also very common following open
Hemolytic Reactions Hemolytic reactions can be: Acute Hemolytic reactions Delayed Hemolytic reactions: The Delayed Hemolytic reactions are seen after a few days of blood transfusion. Acute hemolytic reactions It is usually due to ABO incompatibility (mismatch reaction). The most common cause of these transfusion reactions is clerical error. There is intravascular hemolysis. Incidence is
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Chronic atrial fibrillation (A fib) has an incidence of 0.4% in the general population (approximately 10% of those more than 60 years of age) and many of these patients are admitted to intensive or intermediate care units for reasons unrelated to this diagnosis. Chronic atrial fibrillation needs to be clearly differentiated from new-onset atrial fibrillation
The postoperative management of a kidney transplant recipient requires meticulous monitoring of urine output and electrolyte levels. Renal allografts will not necessarily make urine as soon as they are reperfused. Depending on the particular center, the incidence of delayed graft function ranges from 5% to 15% in cadaveric and from 0% to 5% in live
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Fetal distress can be caused by a host of factors; most notably, hypoxemia and hypovolemia are dangerous for the viable fetus. It is not uncommon for a pregnant patient to be affected by critical illness. Examples of nonobstetric maladies that lead to intensive care unit admission among pregnant women are hematologic issues (venous thromboembolism and pulmonary embolus,
Intensive care unit scoring systems or ICU scoring systems like APACHE and SAPS fall into two broad categories. Risk prediction (also called prognostic) models are designed to assess prognosis at the time of admission to the ICU or within the first 24 hours. Severity-of-illness scoring systems are used in the intensive care unit (ICU) setting as tools
The preparation of carbon dioxide gas is needed before it is actually stored in cylinders. The preparation of carbon dioxide gas is done though following steps : 1. From fermentation in the brewing of beer 2. By-product of manufacture of hydrogen in petroleum refining 3. Combustion of other fuels 4. By heating magnesium and calcium
