Introduction to Sevoflurane Sevoflurane is a volatile inhalational anesthetic agent that has gained significant acceptance in modern medical practice, especially for its application in both adult and pediatric anesthesia. As a halogenated ether, its chemical structure features a combination of fluoroalkyl and ether groups, which contributes to its unique properties. Its molecular formula is C4H03F7, […]
The effect of Halothane on the liver is that it causes hepatitis called as halothane hepatitis. Incidence of massive hepatic necrosis as a result of halothane hepatitis is 1 in 35,000. Risk factors for halothane hepatitis are: Multiple exposures is single most important factor. Hypoxia. Middle age. Obesity. Females. Patient with other autoimmune diseases. Pathologic
Isoflurane renal effects are minimal, only 0.2% metabolites are excreted in the urine and fluoride excretion is minimal. In patients for renal transplantation where there is a risk of arrhythmia, due to alteration in plasma electrolyte concentration, release of renin and catecholamines; there is hemodynamic stability. Skeletal muscle tone is reduced to a greater extent
Anesthesia for Interventional Neuroradiology has progressed from minimally invasive therapy to complex interventional radiology. In the past, anesthesiologists used to be called for resuscitation after some catastrophe had occurred. Interventional neuroradiology (or endovascular neurosurgery) is the radiologically guided endovascular approach to lesions of the central nervous system or its related circulatory structures to deliver therapeutic
Doxapram injection Doxapram is a specific respiratory stimulant. It stimulates the respiratory center preferentially and has relatively less effect on cortical and spinal sites. Following intravenous doxapram injection the drug stimulates ventilation and increases cardiac output and work. Doxapram dose It is given in a dose of 1-1.5 mg/kg by intravenous injection. Intravenous infusion can also
Desflurane undergoes very little desflurane metabolism because of low blood/gas and low blood/tissue solubility. However, 0.02% is metabolized during desflurane metabolism with the production of trifluoroacetic acid which may interact with hepatic proteins and induce an immune response in susceptible patients. Previous exposure to halothane may produce antibodies. In desflurane metabolism , the elimination is almost exclusively by
Wong baker pain assessment tool is used in the patients who do not have appropriate cognitive level to use a number scale, like lay persons or children. The patient then points out to face best represents how he/she is feeling at that point of time. The patient must be explained correlation between each face and
Functioning of Isoflurane cerebral blood flow is discussed here. Isoflurane reduces cerebral metabolism and so the oxygen consumption is reduced. At 1 MAC there is a 23% reduction in CMRO2. Isoflurane cerebral blood flow is not associated with seizure activity as opposed to Enflurane. The EEG shows progressive development of slow waves after an initial
These are classified as high flow Oxygen Delivery Devices and low flow Oxygen Delivery Devices. Classification of Oxygen Delivery Devices in non intubated patient : 1. High flow (fixed performance) delivery systems. 2. Low flow (variable performance) delivery systems. As the high flow oxygen delivery devices have already been discussed, let us see what the low
Flow Volume Loops are more sensitive and informative in detecting pulmonary diseases than conventional spirometry. Modem microprocessor controlled recording spirometers automatically generate these flow volume loops. The following are the parameters that are assessed in the Flow volume loops. TV= Tidal volume IRV = Inspiratory reserve volume IC = Inspiratory capacity ERV = Expiratory reserve
