There is an ongoing debate as to whether propofol EEG exhibits pro- or anticoagulant effects, and whether it should be used in patients with epilepsy.
In a prospective study, Meyer et al documented propofol EEG as a sedative-hypnotic agent with anticonvulsant properties as shown by depression of spike-wave patterns in children with epilepsy and by the absence of seizure-like phenomena of epileptic origin.
Wang et al. in their study found propofol in producing similar dose-dependent effects on EEG activity in patients with or without a history of seizure disorders.
Induction of anaesthesia with higher doses of propofol (> 1.5 mg/kg) in neurosurgical patients with well controlled seizure disorder is safe. However, smaller sedative doses should be administered with caution to epileptic patients.
Propofol EEG provides neuroprotection by preventing and reversing the inhibition of excitatory amino acid uptake in astrocytes exposed to oxidative stress.
Propofol changes on the EEG are significant.
The ability of propofol EEG to defend against peroxide-induced inhibition of glutamate clearance may prevent the pathologic increase in extracellular glutamate at synapses, and thus delay or prevent the onset of excitotoxic neuronal death.
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