Phenobarbital Schedule

The Phenobarbital schedule is listed here. The long-term administration of high doses of thiopental is associated with an increased incidence of nosocomial infections and associated mortality.

Barbiturate coma may cause reversible leucopenia and an increased infection rate. Long-term administration of thiopental may also promote reversible antibiotic-induced bone marrow suppression. Thiopentone depresses T-lymphocyte function.

Loop et al demonstrated that thiopental inhibits the activation of NF-kappab and may thus provide a molecular mechanism for some of the immunosuppressing effects associated with thiopental therapy.

This was about the phenobarbital schedule that we have discussed in considerable detail. Hence phenobarbital or thiopentone can be given in a variety of schedules.

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