Midazolam use is helpful with hypnotic amnesic during maintenance of general anesthesia. It proved superior to thiopental because fewer adjuvant anesthetics are required to maintain an acceptable depth of anesthesia.
Midazolam use , however, cannot be implemented alone to maintain adequate anesthesia. It may be used with inhalational drugs as well.
The MAC of halothane is reduced in a dose related fashion by Midazolam. After use for maintenance of anesthesia, recovery is longer (1—2.5 times) from midazolam than from thiopental.
Gradual awakening in patients who receive midazolam is rarely associated with nausea, vomiting, or emergence excitement. One hour after surgery, patients are equally alert with either midazolam or thiopental.
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