Midazolam effects cerebral metabolic oxygen requirement (CMRO2) by decreasing it and cerebral blood flow, analogous to barbiturates and propofol.
It causes dose-related changes in regional cerebral blood flow in brain regions associated with the normal functioning of arousal, attention, and memory.
Patients with decreased intracranial compliance show little or no change in intra-cranial pressure when midazolam is given at the doses of 0.1 5—0.27 mg/kg.
Similar to thiopental, induction with midazolam effects , does not prevent rise in intracranial pressure associated with direct laryngoscopy for tracheal intubation. Midazolam is a potent anticonvulsant effective in the treatment of status epilepticus.
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