Several effects of ketamine are discussed here.
Ketamine can attenuate important pro-inflammatory key functions of neutrophils in vitro, by inhibiting activated neutrophils, although these inhibitory effects are similar for racemic ketamine and its isomers.
Thus ketamine might have role in limiting tissue injury in sepsis or ischemia/reperfusion.
In the patients with sepsis caused by gram-negative bacteria, ketamine may become advantageous for anesthesia because it may suppress LPS-induced production of proinflammatory cytokines, such as TNF alpha and IL-6.
One of the effects of ketamine is that, Ketamine inhibits platelet aggregation in a concentration dependent manner.
Ketamine inhibits phosphoinositide breakdown and intracellular Ca2 mobilization in human platelets stimulated by collagen. Ketamine also significantly inhibits thromboxane-A2 formation stimulated by collagen.
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