All hypnotics drugs act on different subunits of GABA receptors. Gamma amino butyric acid (GABA): This is a major inhibitory amino acid Neuro Transmitter in the brain; its synthesis from glutamate is catalyzed by the enzyme glutamic acid decarboxylase. It binds to either GABA-A or GABA-B receptor following its release from the presynaptic vesicles. GABA- […]
Nitrous Oxide Effects the brain and induced analgesia or pain relief and anesthesia. Nitrous Oxide Effects includes the cardiovascular system as well. Nitrous oxide is a myocardial depressant and reduces the cardiac output. This is offset by an increase in sympathetic nerve activity resulting in peripheral vasoconstriction and thereby a minimal change in blood pressure.
Benzodiazepines or BDZ are compounds have largely replaced the barbiturates as hypnotics and act as sedatives, anticonvulsants, muscle relaxants and anesthetic agents. Mechanism of action of Benzodiazepines or BDZ Benzodiazepines or BDZ bind selectively to the a subunit of the GABA-A receptors surrounding the chloride channels in the CNS, a site distinct from that to which
IV Anesthesia or intravenous anesthesia is when anesthesia is given through a vein through injections. Anesthesia is usually started or induced with intravenous or IV anesthesia drugs. The different IV Anesthesia drugs are: Thiopental sodium Midazolam Methohexitone Ketamine Etomidate Propofol Some Steroids Ultra short acting barbiturates The ultra-short acting barbiturates administered as IV Anesthesia to
Neuroleptanalgesia Neuroleptanalgesia is method of IV anesthesia which combines at neuroleptic drug with opioid analgesic drug. The most favored combination is neuroleptic droperidol and the analgesic fentanyl. The combination used neuroleptanalgesia induces state which is different from usual general anesthesia. Because the patient is awake during surgery and is cooperative during the operative and surgical
Below is an answer to the simple question what is sleep? What is Sleep? Physiologically, sleep is regarded as absence of wakefulness, where the responses to environmental stimuli are greatly reduced. But, in fact, it is an active state, related to definite anatomic structures as well to specific biogenic amines. Yet, its exact mechanism is
Lesions requiring Cranial Base Surgery represent a heterogeneous group of lesions and vascular malformations associated with cranial base bony structures. These pathologies provide a challenging situation for both neurosurgeon and neuroanaesthesiologist. There is abundance of structures especially vital centers in a relatively smaller infratentorial space. Many patients present with signs and symptoms of brain stem
Emergence from anesthesia has cardiorespiratory, metabolic/endocrine and neurologic consequences. Awakening and extubation after anesthesia are associated with haemodynamic arousal lasting 10-25 minutes. This activation is partially mediated by elevations in catecholamine levels and partially by nociceptive stimuli. The aim of emergence after a neurosurgical procedure is to maintain intracerebral and extra-cerebral homeostasis. This implies maintenance
Cerebral Aneurysm Clipping is one of the important modalities for the treatment of aneuryms apart from coiling so the anesthetic management of such cases is as follows. Skull is a fixed vault and most intracerebral structures are relatively in compressible, hence even a small haemorrhage can result in a significant anatomic distortion producing significant rise in ICP
Postoperative Nausea and Vomiting (PONV) is one of the most distressing experiences associated with surgery, and many patients find it more troublesome than postoperative pain itself. It is not only very uncomfortable to the patient in the postoperative period but it also delays the time of starting enteral feeding and normal functions. Especially in day care
