Anesthesia

ACDU Scale

McNarry and Goldhill compared ACDU Scale (Alert, Confused, Drowsy, Unresponsive) and AVPU scale (Alert, responds to Voice, responds to Pain, Unresponsive) by the American college of surgeons with GCS scale for neurological assessment of critically ill ward patients. Just like GCS the ACDS Scale is a method to assess the neurological status and level of […]

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Desflurane

Desflurane is an inhalational agent used in anesthesia that is similar to isoflurane except the chlorine atom of isoflurane is replaced by fluorine atom which produces significant changes in physical properties. Physical Properties of Desflurane : It is colorless liquid. Pungent odor, so induction is not pleasant. Vapor pressure of Desflurane is very high (681

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Desflurane cardiovascular effects

Desflurane cardiovascular effects are mentioned here. There is a decrease in systemic vascular resistance and peripheral vasodilatation. Cardiac depression, a dose-dependent tachycardia and fall in blood pressure are seen. Along with N20 this effect is minimal. Splanchnic and renal blood flow is preserved. Desflurane is a direct coronary vasodilator. A rapid increase in concentration of

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Halothane neuromuscular junction

Halothane neuromuscular junction effect produces moderate muscle relaxation, it increases the degree and duration of relaxation produced by nondepolarizing muscle relax- ants. The action is at the postjunctional membrane. There is relaxation of the uterine muscle, which is useful in podalic version procedure but may hinder uterine contraction postpartum. Halothane neuromuscular junction effect may produce

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Neuroleptic malignant syndrome

Neuroleptic malignant syndrome (NMS) is a clinical syndrome consisting of four primary features: rigidity, altered mental status, hyperthermia, and autonomic instability. It occurs in the setting of the use of dopamine-blocking agents or the withdrawal of dopamine-enhancing medications. Neuroleptic malignant syndrome Epidemiology Incidence of Neuroleptic malignant syndrome is estimated at 0.1% to 2%. There is

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Metabolism of volatile anesthetics

Metabolism of volatile anesthetics is discussed here. Once thought to be chemically inert, inhalation agents, especially the older ones, undergo significant metabolism, bio-transformation and breakdown to potentially toxic intermediates. This process is affected by age, disease, drug interaction and genetics. Inhalation agents are administered in great excess of the amount metabolized unlike other drugs. For

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