Benzodiazepines effects

Benzodiazepines effects appear to produce all their pharmacologic effects by facilitating the actions of gamma-amino butyric acid (GABA).

The area where it causes it effect is the principal inhibitory neurotransmitter in the CNS by enhancing their affinity towards GABA receptors leading to increased chloride conductance and hyperpolarization of the postsynaptic cell membrane, and thereby rendering them resistant to further excitation.

The mechanism of the benzodiazepine in dealing with GABA receptors has found itself in enhancing its use in anesthesia related applications.

This resistance to excitation is presumed to be the mechanism for most of its actions. This is often seen when studying the action that results from the benzodiazepines effects .


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