Methoxyflurane even though being the most potent anesthetic gas to be discovered till now, its use can been restricted due to the different complications that can arise from its usage.

Below is a brief discussion on this inhalational agent.

Physical Properties of Methoxyflurane

• It has sweet odor.

• It is non irritant.

• It is non inflammable.

• It has a boiling point more than that of water (104°C).

• It is highly soluble in rubber tubing of closed circuit and this can result in decreased levels of gases at the patients end.

• It also undergoes the maximum metabolism among all the inhalational anesthetics.

Anesthetic Properties of Methoxyflurane

• It is the most potent inhalational agent (MAC 0.16%).

Methoxyflurane has the slowest induction and recovery (blood gas coefficient 15).

• It is a good analgesic.

• It is a good muscle relaxant.

Systemic Effects of Methoxyflurane

Cardiovascular system: Sensitizes heart to adrenaline. It causes bradycardia that is decrease in heart rate and also decreases the cardiac output.

Liver: It is hepatotoxic and result in damage to the liver.

Renal: Methoxyflurane yields highest concentration of fluoride (F) which can damage the tubules and can cause vasopressin resistant high output (polyuric) renal failure.

Contraindications of Methoxyflurane

• Not to be used with closed circuit (reacts with rubber tubing of closed circuit).

• Renal diseases.

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