Local Anesthetic Duration of Action depends on a number of factors. The important factors effecting the duration of action of Local anesthetics are given below: 1. Dose: Increased dose of the local anesthetic increases the duration of action of the nerve block. 2. Pharmacokinetic profile of drug: It includes: i. Plasma protein binding (Alpha1 acid […]
The intrathecal administration of opioids especially intrathecal morphine has emerged as a popular and effective form of postoperative pain control. Intrathecal opioids are able to provide long-lasting analgesia after a single injection. They work by binding to the µ opioid receptors, which are located in the substantia gelatinosa of the dorsal horn of the spinal
The Local Anesthetics action correlates with lipid solubility. Cm is the minimum concentration of local anesthetic that will block nerve impulse conduction. The Local Anesthetics action depends on number of factors like: i. Dose and concentration: The dose as well as the concentration of the drug is an important determinant of Local Anesthetics Action. ii. pKa:
Adrenaline is frequently used in anesthesia, particularly the regional type. The Adrenaline Mechanism in anesthesia to increase the duration of the block can be easily understood. The adrenaline is usually added to increase the duration of the regional anesthesia or the nerve block. It is frequently used in brachial plexus blocks like the Supraclavicular block
Differential Block refers to the gradual and sequential block of the different type of nerve fibres when they are exposed to a local anesthetic. Small diameter axons are more susceptible to block than large diameter fibers, however myelinated fibers are more sensitive than non myelinated. This is because local anesthetics block the fiber at node
